Journal: Current biology : CB

Article Title: Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons.

doi: 10.1016/j.cub.2015.07.050

Figure Lengend Snippet: Figure 6. The L-Type Calcium Channel Blocker Isradipine Reduces Basal Respiration and Vulnerability to MPP+

Article Snippet: In some experiments, the L-type Ca2+ channel blocker isradipine (Tocris) (1 mM) was added 3 hr before MPP+ or rotenone for acute treatments.

Techniques:

Journal: Annals of Clinical and Translational Neurology

Article Title: Isradipine plasma pharmacokinetics and exposure–response in early Parkinson’s disease

doi: 10.1002/acn3.51300

Figure Lengend Snippet: Baseline demographic and disease characteristics overall and by CL/F tertile among participants randomized to isradipine treatment arm with pharmacokinetic data.

Article Snippet: Plasma concentrations of isradipine were measured using a validated ultra‐performance liquid chromatography method with tandem‐mass spectrometric detection (AIT Bioscience, LLC, Indianapolis, IN).

Techniques: Modification

Journal: Annals of Clinical and Translational Neurology

Article Title: Isradipine plasma pharmacokinetics and exposure–response in early Parkinson’s disease

doi: 10.1002/acn3.51300

Figure Lengend Snippet: Simulated mean isradipine plasma concentration versus time curves at steady state by age. Simulations for each age decade were performed 1000 times. According to pharmacokinetic modeling simulations, average steady‐state plasma maximum concentration ( C max ) for a 60‐year‐old person would have been 3.24 ng/mL, while a 40‐year‐old and 80‐year‐old would have had values of 2.94 and 3.95 ng/mL, respectively.

Article Snippet: Plasma concentrations of isradipine were measured using a validated ultra‐performance liquid chromatography method with tandem‐mass spectrometric detection (AIT Bioscience, LLC, Indianapolis, IN).

Techniques: Concentration Assay

Journal: Annals of Clinical and Translational Neurology

Article Title: Isradipine plasma pharmacokinetics and exposure–response in early Parkinson’s disease

doi: 10.1002/acn3.51300

Figure Lengend Snippet: Population pharmacokinetic model parameter estimates of isradipine from final model and bootstrap analysis.

Article Snippet: Plasma concentrations of isradipine were measured using a validated ultra‐performance liquid chromatography method with tandem‐mass spectrometric detection (AIT Bioscience, LLC, Indianapolis, IN).

Techniques:

Journal: Annals of Clinical and Translational Neurology

Article Title: Isradipine plasma pharmacokinetics and exposure–response in early Parkinson’s disease

doi: 10.1002/acn3.51300

Figure Lengend Snippet: Correlations between outcomes measures and isradipine plasma exposures among participants randomized to isradipine treatment arm.

Article Snippet: Plasma concentrations of isradipine were measured using a validated ultra‐performance liquid chromatography method with tandem‐mass spectrometric detection (AIT Bioscience, LLC, Indianapolis, IN).

Techniques: Modification

Journal: Annals of Clinical and Translational Neurology

Article Title: Isradipine plasma pharmacokinetics and exposure–response in early Parkinson’s disease

doi: 10.1002/acn3.51300

Figure Lengend Snippet: Isradipine pharmacokinetic exposures by tertile exposure groups.

Article Snippet: Plasma concentrations of isradipine were measured using a validated ultra‐performance liquid chromatography method with tandem‐mass spectrometric detection (AIT Bioscience, LLC, Indianapolis, IN).

Techniques: Standard Deviation

Journal: Annals of Clinical and Translational Neurology

Article Title: Isradipine plasma pharmacokinetics and exposure–response in early Parkinson’s disease

doi: 10.1002/acn3.51300

Figure Lengend Snippet: Proportional hazard model hazard ratios (95% confidence intervals) of time to need antiparkinson therapy by isradipine plasma exposure tertile groups (nominal variable) compared to placebo ( n = 166).

Article Snippet: Plasma concentrations of isradipine were measured using a validated ultra‐performance liquid chromatography method with tandem‐mass spectrometric detection (AIT Bioscience, LLC, Indianapolis, IN).

Techniques: